Potassium Carbonate → HCID 59435992, compound

HRID 1802507Notes

Reaction equation

HRID 1802507 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[C:4]([Cl:14])[C:3]=1[NH:15][C:16]1[C:25]2[CH:26]=[CH:27][N:28]=[C:29]([O:30][CH3:31])[C:24]=2[C:23]2[C:18](=[CH:19][CH:20]=[N:21][CH:22]=2)[N:17]=1.C([O-])([O-])=O.[K+].[K+]>CO>[Cl:14][C:4]1[CH:5]=[C:6]([C:8]#[CH:9])[CH:7]=[C:2]([Cl:1])[C:3]=1[NH:15][C:16]1[C:25]2[CH:26]=[CH:27][N:28]=[C:29]([O:30][CH3:31])[C:24]=2[C:23]2[C:18](=[CH:19][CH:20]=[N:21][CH:22]=2)[N:17]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 59436087HCID 59436087, compound

Product 1

HCID 59435992HCID 59435992, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-{2,6-dichloro-4-[(trimethylsilyl)ethynyl]phenyl}-10-methoxypyrido[4,3-c]-1,6-naphthyridin-6-amine (118 mg, 0.25 mmol) in methanol (3 mL) was added K2CO3 (38.4 mg, 0.28 mmol) and stirred at room temperature overnight. The solvents were evaporated and the residue was diluted with ethyl acetate and washed with water followed by brine. The organic layer was dried with sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound.

Workup

  1. customThe solvents were evaporated
  2. additionthe residue was diluted with ethyl acetate
  3. washwashed with water
  4. dry with materialThe organic layer was dried with sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-d774c0604da746e39e799ff3a803f1b6
Source dataset
uspto-grants-2013_01
Patent number
US08349865B2

Reaction notes

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