Hydrochloric Acid → HCID 68634098, compound

HRID 1802821Notes

Reaction equation

HRID 1802821 reaction equation
C([N:8]1[C:16]2[C:11](=[CH:12][C:13]([CH2:20][N:21]3[CH2:26][CH2:25][S:24](=[O:28])(=[O:27])[CH2:23][CH2:22]3)=[CH:14][C:15]=2[N+:17]([O-:19])=[O:18])[C:10]([Br:29])=[C:9]1[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)(OC(C)(C)C)=O.Cl>C(OCC)C>[Br:29][C:10]1[C:11]2[C:16](=[C:15]([N+:17]([O-:19])=[O:18])[CH:14]=[C:13]([CH2:20][N:21]3[CH2:26][CH2:25][S:24](=[O:27])(=[O:28])[CH2:23][CH2:22]3)[CH:12]=2)[NH:8][C:9]=1[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68633737HCID 68633737, compound

Product 1

HCID 68634098HCID 68634098, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-BOC-3-bromo-5-(1,1-dioxo-thiomorpholine-4-yl)methyl-7-nitro-2-phenyl-1H-indole obtained in Step 3 (825 mg, 1.6 mmol) was dissolved in diethylether (5 mL), and then HCl (4M dioxane solution, 5 mL). The reaction solution was stirred for 2 hours at room temperature. At the end of the reaction, removed solvent under reduced pressure and dried to obtain 3-bromo-5-(1,1-dioxo-thiomorpholine-4-yl)methyl-7-nitro-2-phenyl-1H-indole, which was used in the next step without further purification.

Workup

  1. customAt the end of the reaction
  2. customremoved solvent under reduced pressure
  3. customdried

Sources & evidence

ORD record
ord-23d970dbdc294b548657bae1c56cd803
Source dataset
uspto-grants-2013_01
Patent number
US08349885B2

Reaction notes

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