反应详情

The compound (I) may be further treated with a 2-chloroethoxy acetic acid derivative such as 2-chloroethoxy acetamide or 2-chloroethoxy acetate or 2-chloroethoxy acetonitrile in the presence of a base such as sodium carbonate or potassium carbonate, and a solvent such as toluene or xylene to obtain the corresponding [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid derivative which on hydrolysis, for example, using sodium hydroxide gives levocetirizine.