Triethylamine → HCID 54192011, compound

HRID 1803060Notes

Reaction equation

HRID 1803060 reaction equation
[NH2:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][N:4]=1.[CH2:9](N(CC)CC)[CH3:10]>C1COCC1>[CH:2]1[N:1]=[CH:10][CH2:9][N:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=12

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 195092-Pyridinemethanamine

Product 1

HCID 54192011HCID 54192011, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-aminomethyl pyridine (10 mmol) was dissolved together with triethylamine (20 mmol) in THF (50 ml) and a solution of the corresponding bis-imidoylchloride (10 mmol) was added dropwise. Then the solution was refluxed for ca. 4 h and after cooling-down the solvent was removed under reduced pressure. The residue was washed with little cold methanol and subsequently, the residue was recrystallized from acetonitrile or THF.

Workup

  1. temperatureThen the solution was refluxed for ca. 4 h
  2. temperatureafter cooling-down the solvent
  3. customwas removed under reduced pressure
  4. washThe residue was washed with little cold methanol
  5. customsubsequently, the residue was recrystallized from acetonitrile or THF

Sources & evidence

ORD record
ord-78cd227edabb4a47b9ff21c79ea7bae2
Source dataset
uspto-grants-2013_01
Patent number
US08350038B2

Reaction notes

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