Hydrochloric Acid → HCID 54592645, compound

HRID 1803512Notes

Reaction equation

HRID 1803512 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:24])[NH:16][CH2:17][CH2:18][N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[CH:11][CH:10]=1)(C)(C)C.[ClH:26]>CO.CC(O)C>[ClH:26].[ClH:26].[NH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([NH:16][CH2:17][CH2:18][N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:24])=[CH:13][CH:14]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67415523HCID 67415523, compound

Product 1

HCID 54592645HCID 54592645, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3776IsopropanolSolvent

Procedure

To a solution of [4-(2-Pyrrolidin-1-yl-ethylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester (400 mg, 1.15 mmol) in MeOH (30 mL) was added 6M HCl in IPA (25 mL). The mixture was stirred at ambient temperature for 5 h. After this time a precipitate had formed and was filtered and dried to yield the title compound. m/z (M+1) 248.34.

Workup

  1. customAfter this time a precipitate had formed
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-203249260ddd4101b3a65990e2daa5d8
Source dataset
uspto-grants-2013_01
Patent number
US08349836B2

Reaction notes

Loading…