反应详情

(R)-3-(3-Methoxybenzyl)-4-oxocyclopent-2-enyl acetate (0.1 g, 0.38 mmol) was dissolved in THF (1 ml), 3N HCl (5 ml) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction was quenched with saturated NaHCO3 to pH=6.9 and extracted with EtOAc and the organic layer was washed with brine, dried over MgSO4, and evaporated. The resulting residue was purified by chromatography on a silica gel column using hexane-EtOAc as eluent to give the (R)-4-hydroxy-2-(3-methoxybenzyl)cyclopent-2-enone as yellow oil: 71 mg (yield: 85%)

1. customThe reaction was quenched with saturated NaHCO3 to pH=6.9
2. extractionextracted with EtOAc
3. washthe organic layer was washed with brine
4. dry with materialdried over MgSO4
5. customevaporated
6. customThe resulting residue was purified by chromatography on a silica gel column