反应详情

温度

110 °C

In a cylindrical quartz tube were placed 4-fluoro-2-methyl-benzoic acid methyl ester (1.2 g, 7.14 mmol), N-methylpiperazine (0.95 ml, 8.5 mmol), K2CO3 (990 mg, 7.14 mmol) and DMSO (4 ml). The reaction was heated for 20 hours at 110° C. until HPLC revealed the disappearance of the starting-material. DCM (15 ml) was added and the solution was washed twice with water and the organic phase was dried over anhydrous Na2SO4. The crude was purified by flash chromatography (DCM/MeOH 95:5) affording the desired compound (670 mg, 38%).

1. customIn a cylindrical quartz tube were placed
2. washthe solution was washed twice with water
3. dry with materialthe organic phase was dried over anhydrous Na2SO4
4. customThe crude was purified by flash chromatography (DCM/MeOH 95:5)