4-Iodobenzoyl chloride → [4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

HRID 1804044Notes

Reaction equation

HRID 1804044 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:16])[C:7]([N:10]3[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[I:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:16])[C:7]([N:10]3[CH2:11][CH2:12][N:13]([C:22]([C:21]4[CH:25]=[CH:26][C:18]([I:17])=[CH:19][CH:20]=4)=[O:23])[CH2:14][CH2:15]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 743734-Iodobenzoyl chlorideHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484841[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneYield 90%

Procedure

By reaction and treatment in the same manner as in Preparation Example 65 and using 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.42 g) described in Preparation Example 96, 4-iodobenzoyl chloride (1.83 g), the title compound (2.63 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 65

Sources & evidence

ORD record
ord-22ba39c39b1b4dbb87d1b304d413781a
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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