反应详情

To methyl 4-bromo-2-cyanobenzoate (4.76 g) described in Preparation Example 191 was added dimethoxyethane (78 mL), a solution obtained by dissolving lithium hydroxide monohydrate (1.25 g) in water (30 mL) under ice-cooling was added dropwise, and the mixture was stirred for 1 hr. Under ice-cooling, the mixture was neutralized with 1N hydrochloric acid and dimethoxyethane was evaporated. Water was added and the mixture was stirred under ice-cooling. The precipitated crystals were collected by filtration to give the title compound (4.19 g).

1. customa solution obtained
2. temperaturecooling
3. additionwas added dropwise
4. temperatureUnder ice-cooling
5. customwas evaporated
6. additionWater was added
7. stirringthe mixture was stirred under ice-
8. temperaturecooling
9. filtrationThe precipitated crystals were collected by filtration