反应详情

To a mixture of 4-(4-bromo-2-methanesulfonylbenzoyl)-1-(2,4-dimethylphenyl)piperazin-2-one (931 mg), oxazolidin-2-one (209 mg), potassium carbonate (849 mg) and copper (I) iodide (76 mg) were added toluene (2 mL) and N,N′-dimethylethylenediamine (90 μL), and the mixture was refluxed for 8 hr. After cooling, water was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, and the solvent was evaporated. The residue was purified by column chromatography (chloroform:methanol) and recrystallized from a mixed solution of hexane and ethyl acetate to give the title compound (603 mg).

1. temperaturethe mixture was refluxed for 8 hr
2. temperatureAfter cooling
3. extractionthe mixture was extracted with chloroform
4. washThe organic layer was washed with saturated brine
5. customthe solvent was evaporated
6. customThe residue was purified by column chromatography (chloroform:methanol)
7. customrecrystallized from a mixed solution of hexane and ethyl acetate