1-Bromo-2-butanone → HCID 68905741, compound

HRID 1804551Notes

Reaction equation

HRID 1804551 reaction equation
[NH2:1][C:2](=[S:13])[CH2:3][CH2:4][NH:5]C(=O)OC(C)(C)C.[Br:14][CH2:15][C:16](=O)[CH2:17][CH3:18]>C(O)C>[BrH:14].[CH2:17]([C:16]1[N:1]=[C:2]([CH2:3][CH2:4][NH2:5])[S:13][CH:15]=1)[CH3:18]

Participants

4

Reactant 2

HCID 131561-Bromo-2-butanoneHCID 2735653tert-Butyl (3-amino-3-sulfanylidenepropyl)carbamate

Product 1

HCID 68905741HCID 68905741, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.00 g (9.50 mmol) tert.butyl N(3-amino-3-thioxopropyl)carbamate and 1.58 g (10.45 mmol) 1-bromo-2-butanone are refluxed in 40 ml of ethanol for 16 hours with stirring. The reaction mixture is evaporated down, the residue is purified by chromatography.

Workup

  1. customThe reaction mixture is evaporated down
  2. customthe residue is purified by chromatography

Sources & evidence

ORD record
ord-a9189c79f8924629af8c20cb301cbc8c
Source dataset
uspto-grants-2013_01
Patent number
US08354418B2

Reaction notes

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