Trifluoroacetic acid → HCID 24254482, compound

HRID 1804558Notes

Reaction equation

HRID 1804558 reaction equation
[CH2:1]([C:3]1[O:7][C:6]([CH2:8][CH2:9][NH:10]C(=O)OC(C)(C)C)=[N:5][N:4]=1)[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH2:1]([C:3]1[O:7][C:6]([CH2:8][CH2:9][NH2:10])=[N:5][N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57636978HCID 57636978, compound

Product 1

HCID 24254482HCID 24254482, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.95 g (12.23 mmol) tert-butyl [2-(5-ethyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate and 10 ml trifluoroacetic acid are stirred in 100 ml dichloromethane for 24 hours at ambient temperature. Then the mixture is evaporated down, the residue is made basic and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness.

Workup

  1. customThen the mixture is evaporated down
  2. extractionextracted with ethyl acetate
  3. customThe organic phase is dried
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-676548987f224d0baf44f630521d62b1
Source dataset
uspto-grants-2013_01
Patent number
US08354418B2

Reaction notes

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