反应详情

温度

50 °C

2.00 g (22.70 mmol) N-hydroxy-propionamidine are placed in 10 ml dimethylformamide and molecular sieve. 0.999 g (24.97 mmol) sodium hydride (60% in mineral oil) are added. The mixture is stirred for 0.1 hours at 50° C., then 5.00 g (24.60 mmol) methyl3-tert-butoxycarbonylamino-propionate in 20 ml dimethylformamide are added. The reaction mixture is stirred for 3 hours at 50° C. After cooling 15 ml of water are added, and the mixture is suction filtered through Celite. The 2 phases of the filtrate are separated and the organic phase is evaporated down. The residue is purified by chromatography.

1. stirringThe reaction mixture is stirred for 3 hours at 50° C
2. additionare added
3. filtrationfiltered through Celite
4. customThe 2 phases of the filtrate are separated
5. customthe organic phase is evaporated down
6. customThe residue is purified by chromatography