Hydrochloric Acid → [2-(3-Ethyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

HRID 1804567Notes

Reaction equation

HRID 1804567 reaction equation
[CH2:1]([C:3]1[N:7]=[C:6]([CH2:8][CH2:9][NH:10]C(=O)OC(C)(C)C)[O:5][N:4]=1)[CH3:2].[ClH:18]>ClCCl>[ClH:18].[CH2:1]([C:3]1[N:7]=[C:6]([CH2:8][CH2:9][NH2:10])[O:5][N:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 57637085[2-(3-Ethyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 53398851[2-(3-Ethyl-1,2,4-oxadiazol-5-yl)ethyl]amine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

2.05 g (8.50 mmol) tert-butyl [2-(3-ethyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate are placed in 20 ml dichloromethane and 40 ml of 1 molar ethereal hydrochloric acid are added. The reaction mixture is stirred for 16 hours at ambient temperature and 4 hours at 40° C. After the addition of a further 10 ml ethereal hydrochloric acid stirring is continued for 72 hours at ambient temperature. The suspension is evaporated down.

Workup

  1. waitis continued for 72 hours at ambient temperature
  2. customThe suspension is evaporated down

Sources & evidence

ORD record
ord-dffc0a85051f47aea9dff6e1b4a986a0
Source dataset
uspto-grants-2013_01
Patent number
US08354418B2

Reaction notes

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