Tert-butyl 4-(1,3-thiazol-4-yl)piperidine-1-carboxylate → 4-(1,3-Thiazol-4-yl)piperidine

HRID 1804599Notes

Reaction equation

HRID 1804599 reaction equation
[S:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[N:3]=[CH:2]1>Cl.O1CCOCC1>[S:1]1[CH:5]=[C:4]([CH:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 53485228Tert-butyl 4-(1,3-thiazol-4-yl)piperidine-1-carboxylate

Product 1

HCID 392362494-(1,3-Thiazol-4-yl)piperidineYield 94%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The title compound from Step C above (280 mg, 1.04 mmol) was dissolved in 4 M HCl in dioxane (4.0 mL) and stirred at RT for 1 h. The product was concentrated under reduced pressure and dried under high vacuum to give the title compound (i-30) (237 mg, 94%). ESI-MS calculated for C8H12N2S: Exact Mass: 168.07. Found 169.07.

Workup

  1. concentrationThe product was concentrated under reduced pressure
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-bf3b05b113874f4195859adc25366651
Source dataset
uspto-grants-2013_01
Patent number
US08354403B2

Reaction notes

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