Potassium Carbonate → HCID 178435594, compound

HRID 1804662Notes

Reaction equation

HRID 1804662 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]1[C:17]1[NH:21][C:20]2[CH:22]=[CH:23][C:24]([C:26]#[C:27][Si](C)(C)C)=[CH:25][C:19]=2[N:18]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]1[C:17]1[NH:21][C:20]2[CH:22]=[CH:23][C:24]([C:26]#[CH:27])=[CH:25][C:19]=2[N:18]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178504179HCID 178504179, compound

Product 1

HCID 178435594HCID 178435594, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirring solution of compound (S)-2-(5-trimethylsilanylethynyl-1H-benzoimidazol-2-yl)-piperidine-1-carboxylic acid benzyl ester (85.3 mg, 0.197 mmol) in MeOH (2 mL) is added potassium carbonate (27.3 mg, 0.197 mmol). The reaction mixture is stirred at room temperature for 3 hours and concentrated in vacuum to dryness. The residue obtained is used directly in the next step.

Workup

  1. concentrationconcentrated in vacuum to dryness
  2. customThe residue obtained

Sources & evidence

ORD record
ord-c40735aef6aa4674843a10cd705f61d8
Source dataset
uspto-grants-2013_01
Patent number
US08354419B2

Reaction notes

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