反应详情

Iodomethane (0.0362 g, 0.255 mmol) is added to a mixture of 6-(4-methylthiazol-2-ylamino)-5-phenoxypyridin-3-ol (0.255 mmol) and potassium carbonate (0.0794 g, 0.574 mmol) in DMF (3 mL) and stirred overnight at room temperature. The reaction mixture is partitioned between water and ether. The organic layer is washed with water, dried, and concentrated. The residue is purified by silica gel chromatography, eluting with 15-20% EtOAc in hexanes, to afford the title compound.

1. customThe reaction mixture is partitioned between water and ether
2. washThe organic layer is washed with water
3. customdried
4. concentrationconcentrated
5. customThe residue is purified by silica gel chromatography
6. washeluting with 15-20% EtOAc in hexanes