反应详情

A mixture of 4-bromo-3-methoxyphenol (21 g), benzyl bromide (13.5 ml), potassium carbonate (21.4 g) and acetone (200 ml) was stirred at room temperature for 24 h. The insoluble materials were removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1) to give 4-benzyloxy-2-methoxybromobenzene (25 g) as an oil.

1. customThe insoluble materials were removed by filtration
2. concentrationthe filtrate was concentrated in vacuo
3. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1)