D-Psicose → 4-(4H-1,2,4-triazol-3-yl)aniline

HRID 1807199Notes

Reaction equation

HRID 1807199 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[NH:14][N:13]=[CH:12][N:11]=2)=[CH:6][CH:5]=1)([O-])=O.OCC1(OC[C@@H](O)[C@@H](O)[C@H]1O)O>C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[NH:14][N:13]=[CH:12][N:11]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 441036D-PsicoseHCID 28252246219-52-9

Product 1

HCID 30527324-(4H-1,2,4-triazol-3-yl)aniline

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

5-(4-Nitro-phenyl)-1H-[1,2,4]triazole (510 mg) was suspended in 50 mL of ethyl acetate and 56 mg of 10% Pd/C was added. The mixture was hydrogenated under 50 Psi for 100 min. The mixture was filtered and the filtrate was concentrate to give a solid. 497 mg

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrate
  3. customto give a solid

Sources & evidence

ORD record
ord-e229335c2e8c4acab06ff3ec9c8d26d4
Source dataset
uspto-grants-2013_01
Patent number
US08354444B2

Reaction notes

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