HCID 59276872, compound → HCID 59277199, compound

HRID 1807430Notes

Reaction equation

HRID 1807430 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[N:7]1[C:15]2[C:10](=[CH:11][C:12]([N+:16]([O-])=O)=[CH:13][CH:14]=2)[CH2:9][CH2:8]1>O1CCCC1.[Pd]>[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[N:7]1[C:15]2[C:10](=[CH:11][C:12]([NH2:16])=[CH:13][CH:14]=2)[CH2:9][CH2:8]1

Participants

4

Reactant 1

HCID 59276872HCID 59276872, compound

Product 1

HCID 59277199HCID 59277199, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

170 mg 1-(1-methyl-1H-imidazol-2-yl)-5-nitro-2,3-dihydro-1H-indole are dissolved in 20 ml of tetrahydrofuran. To this are added 20 mg palladium on charcoal (10%) and the mixture is hydrogenated for 1 hour at ambient temperature. Then the catalyst is filtered off and the solvent is eliminated in vacuo. The crude product is extracted from diethyl ether.

Workup

  1. filtrationThen the catalyst is filtered off
  2. extractionThe crude product is extracted from diethyl ether

Sources & evidence

ORD record
ord-78ed9dc2d34f41dbb9b772d263595b75
Source dataset
uspto-grants-2013_01
Patent number
US08357689B2

Reaction notes

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