HCID 178467949, compound → HCID 59277341, compound

HRID 1807435Notes

Reaction equation

HRID 1807435 reaction equation
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([N:9]1[C:17]2[C:12](=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=2)[CH2:11][CH2:10]1)=[NH:8])C>FC(F)(F)C(O)=O>[NH:6]1[CH:5]=[CH:4][N:8]=[C:7]1[N:9]1[C:17]2[C:12](=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=2)[CH2:11][CH2:10]1

Participants

3

Reactant 1

HCID 178467949HCID 178467949, compound

Product 1

HCID 59277341HCID 59277341, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
60 °C

Procedure

470 mg N-(2,2-diethoxy-ethyl)-5-nitro-2,3-dihydro-indole-1-carboxamidine are dissolved in 8 ml trifluoroacetic acid and the mixture is heated to 60° C. for 3 hours. Then the solvent is eliminated in vacuo and the residue is chromatographed on aluminium oxide (dichloromethane/methanol 99:1 to 70:30).

Workup

  1. customthe residue is chromatographed on aluminium oxide (dichloromethane/methanol 99:1 to 70:30)

Sources & evidence

ORD record
ord-ea5e7ea682124fc5890c22b0468bac5b
Source dataset
uspto-grants-2013_01
Patent number
US08357689B2

Reaction notes

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