Dimethylformamide → N-(3-(4-chloro-1-methyl-1H-pyrazol-5-yl)-4-hydroxyphenyl)-2-fluoro-4-methoxybenzamide

HRID 180760Notes

Reaction equation

HRID 180760 reaction equation
[CH:28]([N:29]([CH2:30][CH3:31])[CH:32]([CH3:33])[CH3:34])([CH3:35])[CH3:36].[Cl:61][CH2:62][Cl:63].[F:16][c:17]1[c:18]([C:19](=[O:20])[OH:21])[cH:22][cH:23][c:24]([O:26][CH3:27])[cH:25]1.[NH2:1][c:2]1[cH:3][c:4](-[c:9]2[c:10]([Cl:15])[cH:11][n:12][n:13]2[CH3:14])[c:5]([OH:8])[cH:6][cH:7]1.[O:64]=[CH:65][N:66]([CH3:67])[CH3:68].[P-:37]([F:38])([F:39])([F:40])([F:41])([F:42])[F:43].[n:44]1([O:45][C:46]([N:47]([CH3:48])[CH3:49])=[N+:50]([CH3:51])[CH3:52])[c:53]2[n:54][cH:55][cH:56][cH:57][c:58]2[n:59][n:60]1>>[NH:1]([c:2]1[cH:3][c:4](-[c:9]2[c:10]([Cl:15])[cH:11][n:12][n:13]2[CH3:14])[c:5]([OH:8])[cH:6][cH:7]1)[C:19]([c:18]1[c:17]([F:16])[cH:25][c:24]([O:26][CH3:27])[cH:23][cH:22]1)=[O:20]

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 27745422-Fluoro-4-methoxybenzoic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 1363880184-Amino-2-(4-chloro-1-methyl-1H-pyrazol-5-yl)phenol

Product 1

HCID 136388017N-(3-(4-chloro-1-methyl-1H-pyrazol-5-yl)-4-hydroxyphenyl)-2-fluoro-4-methoxybenzamide

Sources & evidence

ORD record
ord-77d50370063848f6b3e5fc87dea47f53
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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