Triphenylphosphine → HCID 58092761, compound

HRID 1807692Notes

Reaction equation

HRID 1807692 reaction equation
[N:1]([CH2:4][C@@H:5]1[CH2:9][CH2:8][N:7]([C@H:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])[C@@H:6]1[C:18]([NH2:20])=[O:19])=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[NH2:1][CH2:4][C@@H:5]1[CH2:9][CH2:8][N:7]([C@H:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH3:11])[C@@H:6]1[C:18]([NH2:20])=[O:19]

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 58092758HCID 58092758, compound

Product 1

HCID 58092761HCID 58092761, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of (2S,3S)-3-azidomethyl-1-((S)-1-phenyl-ethyl)-pyrrolidine-2-carboxylic acid amide (Stage 36.3) (0.723 mmol) and triphenylphosphine (0.867 mmol) in THF (3 mL) was stirred at rt for 25 h. The reaction mixture was concentrated to afford the crude title compound as a light brown solid. HPLC: tR 3.53 min (method H); ESI-MS: [M+H]+ 248.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-0d9ee23ccb7e4623a90e23b87cccb040
Source dataset
uspto-grants-2013_01
Patent number
US08357707B2

Reaction notes

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