反应详情

(4-Aminophenyl)(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-piperazin-1-yl)methanone (0.217 mmol, 0.1 g) and diisopropylethylamine (0.737 mmol, 0.122 mL, 0.095 g) were stirred in dichloromethane at room temperature. Triphosgene (0.080 mmol, 0.024 g) was added and the reaction mixture stirred for 30 minutes. Isopropylamine (0.433 mmol, 0.037 mL, 0.026 g) was added and the reaction stirred for a further 30 minutes. The reaction mixture was concentrated under vacuum and purified by reverse phase acidic preparative HPLC to afford the title compound (10 mg).

1. stirringthe reaction stirred for a further 30 minutes
2. concentrationThe reaction mixture was concentrated under vacuum
3. custompurified by reverse phase acidic preparative HPLC