反应详情

To a stirring solution of 1-(4-(4-(4-(2-(tert-butyldimethylsilyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl)benzyl)piperazine-1-carbonyl)-2-chlorophenyl)-3-(2-hydroxy-2-methylpropyl)urea (0.262 mmol, 190 mg) in tetrahydrofuran (1 mL) was added potassium fluoride (50% weight on celite) (0.524 mmol, 60.9 mg). The resulting suspension was stirred at room temperature for 16 hours. The reaction mixture was filtered through celite and concentrated under vacuum. The resulting residue was purified by SCX chromatography, followed by column chromatography (5-10% methanol in dichloromethane) to afford the title compound (55.5 mg).

1. filtrationThe reaction mixture was filtered through celite
2. concentrationconcentrated under vacuum
3. customThe resulting residue was purified by SCX chromatography