Methanol → 6-tert-Butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]2[c:12]([cH:13][cH:14]1)[C:11](=[O:15])[N:10]([c:16]1[c:17]([CH2:18][O:19][C:20](=[O:21])[CH3:22])[c:23](-[c:27]3[cH:28][n:29]([CH3:49])[c:30](=[O:48])[c:31]([NH:33][c:34]4[n:35][cH:36][c:37]([C:40](=[O:41])[N:42]5[CH2:43][CH2:44][O:45][CH2:46][CH2:47]5)[cH:38][cH:39]4)[cH:32]3)[cH:24][cH:25][cH:26]1)[CH2:9][CH2:8]2.[CH2:56]1[O:57][CH2:58][CH2:59][CH2:60]1.[CH3:50][OH:51].[Li+:55].[OH-:54].[OH2:52].[OH2:53]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]2[c:12]([cH:13][cH:14]1)[C:11](=[O:15])[N:10]([c:16]1[c:17]([CH2:18][OH:19])[c:23](-[c:27]3[cH:28][n:29]([CH3:49])[c:30](=[O:48])[c:31]([NH:33][c:34]4[n:35][cH:36][c:37]([C:40](=[O:41])[N:42]5[CH2:43][CH2:44][O:45][CH2:46][CH2:47]5)[cH:38][cH:39]4)[cH:32]3)[cH:24][cH:25][cH:26]1)[CH2:9][CH2:8]2Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-97f33a5d04b84527817d0adc35e14b9f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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