Hydrochloric Acid → HCID 87119465, compound

HRID 1808657Notes

Reaction equation

HRID 1808657 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][C:4](=[O:7])[N:3]1[O:8][C:9](=[O:24])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][N:18]=C(OCC)C.[ClH:25]>C1COCC1>[ClH:25].[O:7]=[C:4]1[CH2:5][CH2:6][C:2](=[O:1])[N:3]1[O:8][C:9](=[O:24])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:17][NH2:18]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 86603903HCID 86603903, compound

Product 1

HCID 87119465HCID 87119465, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent3×

Procedure

To a solution of 6 (5.8 g, 17 mmol) in THF (30 mL) was added a mixture of HCl and THF (4 mL, 2 mL of c.HCl and 2 mL of THF. The reaction mixture was stirred for 4 h, concentrated to a wet solid and washed with 5% EtOAc/hexane. The product solidified (hygroscopic) under vacuum was used without further purification. 1H NMR (DMSO-d6): δ 1.28-1.37 (6H, m), 1.57-1.65 (4H, m), 2.65 (2H, t, J=7.3), 2.82 (4H, s), 4.02 (2H, t, J=6.3), 11.09 (3H, br s).

Workup

  1. concentrationconcentrated to a wet solid
  2. washwashed with 5% EtOAc/hexane
  3. customwas used without further purification

Sources & evidence

ORD record
ord-affa46dcef1a421ba88af77d65e24c3e
Source dataset
uspto-grants-2013_01
Patent number
US08361442B2

Reaction notes

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