HCID 59587918, compound → HCID 44595148, compound

HRID 1808910Notes

Reaction equation

HRID 1808910 reaction equation
[N:1]([C@@H:4]1[C@@H:8]([O:9][CH2:10][C:11]#[C:12][CH3:13])[CH2:7][N:6]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:5]1)=[N+:2]=[N-:3]>C1(C)C(C)=CC=CC=1>[CH3:13][C:12]1[N:3]=[N:2][N:1]2[C:11]=1[CH2:10][O:9][C@H:8]1[CH2:7][N:6]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:5][C@H:4]21

Participants

3

Reactant 1

HCID 59587918HCID 59587918, compound

Product 1

HCID 44595148HCID 44595148, compoundYield 47.9%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Example 54 can be prepared in the same manner as example 46 from (3S,4S)-tert-butyl 3-azido-4-(but-2-ynyloxy)pyrrolidine-1-carboxylate (115 mg, 0.41 mmol) and xylene (10 ml), afforded the titled compound (55 mg, 47%) as white solid. M.p. 195-196° C.

Sources & evidence

ORD record
ord-8e37d398e3fd412c9ecd9ba4eddb8839
Source dataset
uspto-grants-2013_01
Patent number
US08362011B2

Reaction notes

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