HCID 59587932, compound → HCID 44595149, compound

HRID 1808911Notes

Reaction equation

HRID 1808911 reaction equation
[N:1]([C@@H:4]1[C@@H:8]([O:9][CH2:10][C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:7][N:6]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:5]1)=[N+:2]=[N-:3]>C1(C)C(C)=CC=CC=1>[C:13]1([C:12]2[N:3]=[N:2][N:1]3[C:11]=2[CH2:10][O:9][C@H:8]2[CH2:7][N:6]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH2:5][C@H:4]32)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 1

HCID 59587932HCID 59587932, compound

Product 1

HCID 44595149HCID 44595149, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Example 55 can be prepared in the same manner as example 46 from (3S,4S)-tert-butyl 3-azido-4-(3-phenylprop-2-ynyloxy)pyrrolidine-1-carboxylate (120 mg, 0.35 mmol) and xylene (6 ml), afforded the titled compound (68 mg, 57%) as white solid. M.p. 236-237° C.

Sources & evidence

ORD record
ord-2ca39efd73f540708d89083490057bd7
Source dataset
uspto-grants-2013_01
Patent number
US08362011B2

Reaction notes

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