反应详情

温度

60 °C

cis-(Octahydro-quinolin-1-yl)-(5-piperidin-4-yl-thiophen-3-yl)-methanone (0.029 g, 0.087 mmol) was dissolved MeCN (1 mL) and potassium carbonate (36 mmol) was added followed by 2-bromoethanol (22 mg). The reaction was heated to 60° C. and stirred for 5 hours. The product was purified by flash chromatography on a SCX-2 cartridge, eluting with acetonitrile and then 2 M ammonia in methanol. The residue was further purified by HPLC, eluting with 10%-98% acetonitrile in water (0.1% formic acid). The fractions containing the desired product were concentrated under vacuum to give the title compound (0.046 g). LCMS m/z 377.17 min [M+H]+ RT=6.45 min (Analytical Method 2).

1. additionwas added
2. customThe product was purified by flash chromatography on a SCX-2 cartridge
3. washeluting with acetonitrile
4. customThe residue was further purified by HPLC
5. washeluting with 10%-98% acetonitrile in water (0.1% formic acid)
6. additionThe fractions containing the desired product
7. concentrationwere concentrated under vacuum