Chloroiodomethane → HCID 86641103, compound

HRID 1809608Notes

Reaction equation

HRID 1809608 reaction equation
C([N-]C(C)C)(C)C.[Li+].[F:9][C:10]1([C:23]([O:25]C)=O)[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][CH2:11]1.[Cl:27][CH2:28]I>>[Cl:27][CH2:28][C:23]([C:10]1([F:9])[CH2:11][CH2:12][N:13]([C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH2:14][CH2:15]1)=[O:25]

Participants

4

Reactant 3

HCID 11644ChloroiodomethaneHCID 2724682Lithium diisopropylamideHCID 67487447HCID 67487447, compound

Product 1

HCID 86641103HCID 86641103, compoundYield 78.2%

Procedure

Prepared according to the method of Example 60, Step A, using lithium diisopropylamide (12.8 mL, 19.1 mmol), 1-tert-butyl 4-methyl 4-fluoropiperidine-1,4-dicarboxylate (1.0 g, 3.83 mmol) and chloroiodomethane (2.70 g, 15.3 mmol). Obtained 0.837 g (78.2% yield) of the desired compound.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4b3fd4aaf7e44aab86ca6b372a19f052
Source dataset
uspto-grants-2013_01
Patent number
US08362037B2

Reaction notes

Loading…