Phenacyl bromide → HCID 178462470, compound

HRID 1809962Notes

Reaction equation

HRID 1809962 reaction equation
[CH2:1]([NH:3][C:4](=[S:16])[NH:5][C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][CH:7]=1)[CH3:2].Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=O>CO>[CH2:1]([N:3]1[C:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:18][S:16]/[C:4]/1=[N:5]\[C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][CH:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 6259Phenacyl bromideHCID 726326HCID 726326, compound

Product 1

HCID 178462470HCID 178462470, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 4-(3-ethylthioureido)benzoate (2-3) (50 mg, 0.19 mmol) and 2-bromoacetophenone (39.8 mg, 0.20 mmol) in MeOH (1 mL) is heated to 80° C. for 2 hours and then cooled to room temperature and concentrated to provide (Z)-methyl 4-(3-ethyl-4-phenylthiazol-2(3H)-ylideneamino)benzoate (2-4).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-9dd8e575ba974c6893ed5344b6d5fd97
Source dataset
uspto-grants-2013_01
Patent number
US08362050B2

Reaction notes

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