1,1'-Carbonyldiimidazole → HCID 86639124, compound

HRID 1810054Notes

Reaction equation

HRID 1810054 reaction equation
[CH3:1][O:2][C:3](=[O:12])[CH2:4][S:5][C:6]1[S:10][C:9]([NH2:11])=[N:8][CH:7]=1.C1N=CN([C:18](N2C=NC=C2)=[O:19])C=1.[CH3:25][CH:26]1[CH2:31][CH2:30][CH:29]([NH:32][CH2:33][C:34]([CH3:42])([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH3:35])[CH2:28][CH2:27]1>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH3:1][O:2][C:3](=[O:12])[CH2:4][S:5][C:6]1[S:10][C:9]([NH:11][C:18]([N:32]([CH:29]2[CH2:30][CH2:31][CH:26]([CH3:25])[CH2:27][CH2:28]2)[CH2:33][C:34]([CH3:42])([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH3:35])=[O:19])=[N:8][CH:7]=1

Participants

6

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 24704801Methyl 2-[(2-amino-5-thiazolyl)thio]acetateHCID 54886392HCID 54886392, compound

Product 1

HCID 86639124HCID 86639124, compoundYield 36.1%

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

To a mixture of (2-amino-thiazol-5-ylsulfanyl)-acetic acid methyl ester (416 mg, 2.04 mmol) in CH2Cl2 (30 mL) was added CDI (496 mg, 3.06 mmol) and DMAP (25 mg, 0.21 mmol) at room temperature. The reaction mixture was stirred at rt for 1.5 h, then (4-methyl-cyclohexyl)-(2-methyl-2-phenyl-propyl)-amine (500 mg, 2.04 mmol) was added. The mixture was stirred for 16 h at room temperature. The solvent was removed at reduced pressure and the residue was purified by preparative HPLC to give {2-[3-(4-methyl-cyclohexyl)-3-(2-methyl-2-phenyl-propyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid methyl ester (350 mg).

Workup

  1. stirringThe mixture was stirred for 16 h at room temperature
  2. customThe solvent was removed at reduced pressure
  3. customthe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-78fba910f41f4fcfa01519bc6b4774cb
Source dataset
uspto-grants-2013_01
Patent number
US08362049B2

Reaction notes

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