反应详情

To a solution of 2-bromo-3-hydroxybenzaldehyde (0.5 g, 2.4 mmol) was added potassium carbonate (0.77 g, 5.6 mmol), and the mixture was stirred for 5 minutes. Iodomethane (0.17 mL, 2.7 mmol) was added, and the reaction was stirred at room temperature for 2 hours. The mixture was diluted with H2O (30 mL) and EtOAc (30 mL), and the organic layer was washed with 1N aqueous NaOH, then brine, dried over Na2SO4, decanted, and concentrated. The residue was purified by silica gel chromatography (0-60% EtOAc in hexanes) to give the title compound.

1. stirringthe reaction was stirred at room temperature for 2 hours
2. washthe organic layer was washed with 1N aqueous NaOH
3. dry with materialbrine, dried over Na2SO4
4. customdecanted
5. concentrationconcentrated
6. customThe residue was purified by silica gel chromatography (0-60% EtOAc in hexanes)