Oxalyl chloride → 2-(3-Bromo-5-chloro-phenyl)-propionyl chloride

HRID 1810584Notes

Reaction equation

HRID 1810584 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:9]([CH3:13])[C:10](O)=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C(Cl)(=O)C([Cl:17])=O>C(Cl)Cl.CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:9]([CH3:13])[C:10]([Cl:17])=[O:11])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 574588082-(3-Bromo-5-chlorophenyl)propanoic acid

Product 1

HCID 574588092-(3-Bromo-5-chloro-phenyl)-propionyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-(3-bromo-5-chloro-phenyl)-propionic acid (0.87 g, 3.3 mmol) in CH2Cl2 (10 mL) was added oxalyl chloride (0.63 mL, 6.6 mmol) and DMF (2 drops), and the reaction was stirred for 15 minutes and then concentrated to give the title compound.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-f32ad04c187a4298acd349e485143b9a
Source dataset
uspto-grants-2013_01
Patent number
US08362044B2

Reaction notes

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