Dimethylformamide → HCID 14155580, compound

HRID 1810946Notes

Reaction equation

HRID 1810946 reaction equation
[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=P(Cl)(Cl)Cl.CN([CH:26]=[O:27])C>>[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([CH:26]=[O:27])=[CH:15][CH:16]=2)[CH2:11][CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 24813Phosphorus oxychlorideHCID 122883501-benzyl-1,2,3,4-tetrahydroquinoline

Product 1

HCID 14155580HCID 14155580, compound

Procedure

The procedure was carried out as described previously in step (a) of Example 5 with Compound 5 (0.42 g, 1.88 mmol), POCl3 (355 μL, 3.76 mmol), and DMF (3.5 mL). Compound 6 was obtained (0.36 g) as a viscous liquid and used without any further purification. The structure of Compound 6 is given below:

Sources & evidence

ORD record
ord-65a25e7a99a944fc98cc83be4785b8ad
Source dataset
uspto-grants-2013_01
Patent number
US08362250B2

Reaction notes

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