Trifluoroacetic acid → HCID 66599945, compound

HRID 1810959Notes

Reaction equation

HRID 1810959 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20](=[O:28])[NH:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30]>C(Cl)Cl>[F:32][C:31]([F:34])([F:33])[C:29]([OH:35])=[O:30].[C:22]1([NH:21][C:20]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:28])[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59548884HCID 59548884, compound

Product 1

HCID 66599945HCID 66599945, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a vial containing 4-(2-phenylcarbamoyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.438 g, 1.150 mmol) is added 2 mL of CH2Cl2 and 2 mL of TFA. The mixture stirred for 1 h and then concentrated to dryness to give 0.454 g of 4-(2-phenylcarbamoyl-phenyl)-piperazine trifluroacetate in 100% yield.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-fcf02e9dad5847d3b7d528cfc7d19a26
Source dataset
uspto-grants-2013_01
Patent number
US08362249B2

Reaction notes

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