Divinyl sulfone → HCID 59827394, compound

Temperature

45 °C

In a 50 mL round bottom flask, a mixture of 0.5 g of maleimide, 0.61 g of divinylsulfone and 10 g of 1,4-dioxane was heated to 40-50° C. and stirred. To the reaction solution was added 0.67 g of 40% aqueous tetrabutylammonium hydroxide solution. Subsequently, the mixture was stirred at 40-50° C. for 3 more hours. After stopping stirring, the reaction solution was cooled to room temperature and precipitated and dispersed in 100 mL of methanol. The resultant precipitate was filtered, redispersed in a large volume of clean water, filtered again and washed to remove salt. Then, the product was redispersed in 50 mL of methanol, filtered and dried to obtain 0.94 g of N-vinylsulfonylethylmaleimide (yield=61%)

1. stirringSubsequently, the mixture was stirred at 40-50° C. for 3 more hours
2. stirringAfter stopping stirring
3. temperaturethe reaction solution was cooled to room temperature
4. customprecipitated
5. additiondispersed in 100 mL of methanol
6. filtrationThe resultant precipitate was filtered
7. additionredispersed in a large volume of clean water
8. filtrationfiltered again
9. washwashed
10. customto remove salt
11. additionThen, the product was redispersed in 50 mL of methanol
12. filtrationfiltered
13. customdried

ORD record

ord-834772eb6ae5405d81e43b450846fa3f

Source dataset

uspto-grants-2013_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08362276B2