Diethylamine → HCID 86633509, compound

HRID 1811543Notes

Reaction equation

HRID 1811543 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([CH3:20])[C:14]=2[Cl:21])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1.C(NCC)C>COC(C)(C)C>[CH2:5]([NH:12][CH2:13][CH3:14])[CH3:4].[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([CH3:20])[C:14]=2[Cl:21])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 23642285HCID 23642285, compound

Product 1

HCID 86633509HCID 86633509, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Conditions

Temperature
40 °C

Procedure

A suspension of 600 mg 5-Methyl-2-(2′,4′-dichloro-3′-methylanilino)phenylacetic acid (1.85 mmoles) in 6 ml tert. Butyl methyl ether (TBME) is heated to 40° C. 137 mg diethylamine (1.85 mmoles) are dropwise added. The resulting slightly cloudy solution is clarified via hot filtration through a Whatman glasfiber filter. The filter is rinsed with 2 ml TBME of 40° C. The filtrate is allowed to cool slowly.

Workup

  1. filtrationThe resulting slightly cloudy solution is clarified via hot filtration through a Whatman glasfiber
  2. filtrationfilter
  3. washThe filter is rinsed with 2 ml TBME of 40° C
  4. temperatureto cool slowly

Sources & evidence

ORD record
ord-ed1d493daf6b427ba28e49f984a1c39e
Source dataset
uspto-grants-2013_01
Patent number
US08362294B2

Reaction notes

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