2-Methoxyethylamine → HCID 25177309, compound

HRID 1811728Notes

Reaction equation

HRID 1811728 reaction equation
C[O:2]CCN.[CH3:6][O:7][CH2:8][CH2:9][NH:10][C:11]([C@H:13]1[NH:32][C:31](=[O:33])[C:30]2=[CH:34][C:26](=[C:27]([CH3:36])[CH:28]=[C:29]2[CH3:35])[C:25]2=[CH:37][C:21](=[N:22][C:23]([NH2:38])=[N:24]2)[S:20][CH2:19][CH2:18][C:17](=[O:39])[NH:16][CH2:15][CH2:14]1)=[O:12]>>[CH3:6][O:7][CH2:8][CH2:9][NH:10][C:11]([C@H:13]1[NH:32][C:31](=[O:33])[C:30]2=[CH:34][C:26](=[C:27]([CH3:36])[CH:28]=[C:29]2[CH3:35])[C:25]2=[CH:37][C:21](=[N:22][C:23]([NH2:38])=[N:24]2)[S:20][CH2:19][CH2:18][C:17](=[O:39])[NH:16][CH2:15][CH2:14]1)=[O:12].[NH2:38][C:23]1[N:22]=[C:21]2[CH:37]=[C:25]([C:26]3[CH:34]=[C:30]([C:31](=[O:33])[NH:32][C@H:13]([C:11]([OH:12])=[O:2])[CH2:14][CH2:15][NH:16][C:17](=[O:39])[CH2:18][CH2:19][S:20]2)[C:29]([CH3:35])=[CH:28][C:27]=3[CH3:36])[N:24]=1

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 25177309HCID 25177309, compound

Product 2

HCID 25177309HCID 25177309, compoundHCID 59224665HCID 59224665, compound

Procedure

According to the method of Example 2-14 except that 2-methoxyethylamine (15 μl, 0.175 mmol) was used instead of methylamine, (S)-4-amino-18,20-dimethyl-10,16-dioxo-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.12,6]docosa-1(20),2(22),3,5,17(21),18-hexaene-14-carboxylic acid (2-methoxyethyl)amide (Compound 66) (16 mg) was obtained as a white solid material from (S)-4-amino-18,20-dimethyl-10,16-dioxo-7-thia-3,5,11,15-tetraazatricyclo[15.3.1.12,6]docosa-1(20),2(22),3,5,17(21),18-hexaene-14-carboxylic acid (25 mg, 0.058 mmol) obtained in Example 2-13.

Sources & evidence

ORD record
ord-a66eb00636564b938ad48f67fc505745
Source dataset
uspto-grants-2013_01
Patent number
US08362236B2

Reaction notes

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