Methanol → N-(2-(5-cyano-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide

HRID 181184Notes

Reaction equation

HRID 181184 reaction equation
[CH3:84][OH:85].[F:67][c:68]1[c:69]([CH2:70][c:71]2[cH:72][c:73]([C:76](=[O:77])[OH:78])[n:74][o:75]2)[cH:79][c:80]([F:83])[cH:81][cH:82]1.[N:1](=[N+:2]=[N-:3])[CH2:4][CH2:5][c:6]1[c:7]([Si:17]([CH2:18][CH3:19])([CH2:20][CH3:21])[CH2:22][CH3:23])[nH:8][c:9]2[cH:10][cH:11][c:12]([C:15]#[N:16])[cH:13][c:14]12.[O:86]=[CH:87][N:88]([CH3:89])[CH3:90].[P-:43]([F:44])([F:45])([F:46])([F:47])([F:48])[F:49].[c:24]1([P:25]([c:26]2[cH:27][cH:28][cH:29][cH:30][cH:31]2)[c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:38][cH:39][cH:40][cH:41][cH:42]1.[n:50]1([O:51][C:52]([N:53]([CH3:54])[CH3:55])=[N+:56]([CH3:57])[CH3:58])[c:59]2[n:60][cH:61][cH:62][cH:63][c:64]2[n:65][n:66]1>>[NH:1]([CH2:4][CH2:5][c:6]1[c:7]([Si:17]([CH2:18][CH3:19])([CH2:20][CH3:21])[CH2:22][CH3:23])[nH:8][c:9]2[cH:10][cH:11][c:12]([C:15]#[N:16])[cH:13][c:14]12)[C:76]([c:73]1[cH:72][c:71]([CH2:70][c:69]2[c:68]([F:67])[cH:82][cH:81][c:80]([F:83])[cH:79]2)[o:75][n:74]1)=[O:77]

Participants

8

Reactant 7

HCID 887MethanolHCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 11776TriphenylphosphineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 668320395-(2,5-Difluorobenzyl)isoxazole-3-carboxylic acidHCID 866638383-(2-azidoethyl)-2-(triethylsilyl)-1H-indole-5-carbonitrile

Product 1

HCID 66832142N-(2-(5-cyano-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-5-(2,5-difluorobenzyl)isoxazole-3-carboxamide

Sources & evidence

ORD record
ord-87436f67c7b0461d96ec2e4a590f095a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…