2,6-Lutidine → HCID 178444628, compound

HRID 1812642Notes

Reaction equation

HRID 1812642 reaction equation
C#CCCCCC=O.Cc1ccc(C(=O)CBr)cc1>CN1C(=O)[C@H](Cc2ccccc2)N[C@@H]1C(C)(C)C.[Ru++].F[P-](F)(F)(F)(F)F.F[P-](F)(F)(F)(F)F.c1ccc(nc1)-c2ccccn2.c3ccc(nc3)-c4ccccn4.c5ccc(nc5)-c6ccccn6.CN(C)C=O.Cc1cccc(C)n1>C#CCCC[C@@H](C=O)CC(=O)c1ccc(C)cc1.C#CCCC[C@H](C=O)CC(=O)c1ccc(C)cc1

Participants

8

Reactant 3

HCID 79372,6-LutidineHCID 692722-Bromo-4'-methylacetophenoneHCID 11355455Hept-6-ynal

Product 2

HCID 178444628HCID 178444628, compoundHCID 178444629HCID 178444629, compound

Reagents, catalysts & solvents 3

HCID 103098345-Benzyl-2-tert-butyl-3-methyl-4-imidazolidinone, (2S,5S)-CatalystHCID 15198703Tris(2,2'-bipyridine)ruthenium(II) Bis(hexafluorophosphate)CatalystHCID 6228DimethylformamideSolvent5×

Conditions

Temperature
22 °C

Workup

  1. aliquot4 uL mixture of each reacted solution was collected and diluted with 36 uL ACN
  2. addition4 uL mixture of each reacted solution was collected and diluted with 36 uL ACN
  3. additionchiral resolving regent (150 mM in DCM, 40 uL)
  4. additionCuI with DIPEA (400 mM in ACN) 40 uL
  5. additioninternal standard 1-phenylprop-2-yn-1-ol (4) (25 mM in ACN) 40 uL
  6. stirringNo procedure recorded
  7. aliquotAfter the reaction, 10 uL of supernatant for each reaction was transferred to another 96-well plate
  8. additionAfter the reaction, 10 uL of supernatant for each reaction was transferred to another 96-well plate and diluted with 190 uL ACN before the IM-MS analysis

Sources & evidence

ORD record
ord-c47cad778a9d42e398932f50fc3b728f
Source dataset
Dataset from `Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery`

Reaction notes

Loading…