HCID 22505093, compound → HCID 22505002, compound

HRID 1814037Notes

Reaction equation

HRID 1814037 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]2[CH:14]([O:15]2)[CH2:13]1.[H][H]>[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[C:4]([F:11])[C:3]=1[N:12]1[CH2:17][CH:16]2[CH:14]([O:15]2)[CH2:13]1

Participants

5

Reactant 2

HCID 22505093HCID 22505093, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22505002HCID 22505002, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

10% Palladium on carbon (0.02 g) was added to 3-(2,6-difluoro-4-nitro-phenyl)-6-oxa-3-aza-bicyclo[3.1.0]hexane (0.2 g, 0.83 mmol) dissolved in ethyl acetate (8.0 mL). The flask was charged with hydrogen gas and the mixture was stirred at room temperature for 3 h. The reaction mixture was filtered through celite and the solvent removed to get the title compound which was used directly in the next reaction.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe solvent removed

Sources & evidence

ORD record
ord-a86c43f291124a21a6ab0c32345eab09
Source dataset
uspto-grants-2005_04
Patent number
US06875784B2

Reaction notes

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