Methyl iodide → 1-Bromo-2-methoxy-3-nitrobenzene

HRID 1814202Notes

Reaction equation

HRID 1814202 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1[OH:11].CI.[C:14](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1[O:11][CH3:14]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 135454532-Bromo-6-nitrophenol

Product 1

HCID 225057131-Bromo-2-methoxy-3-nitrobenzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 2-bromo-6-nitrophenol (10.8 g; 0.0495 mol.), methyl iodide (3.4 mL; 0.00545 mol.) and potassium carbonate (8.2 g; 0.0592 mol.) in acetone (250 mL) was stirred and heated under reflux for 24 h.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 24 h.

Sources & evidence

ORD record
ord-1e03a1ea4eea434e9b2261565b8eb06e
Source dataset
uspto-grants-2005_04
Patent number
US06875786B2

Reaction notes

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