p-Toluenesulfonic acid → HCID 178516922, compound

HRID 1814232Notes

Reaction equation

HRID 1814232 reaction equation
[NH2:1][C:2]1[NH:7][C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:5][C:4](=[O:16])[C:3]=1[S:17][CH2:18][C:19]([O:21]CC)=O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[C:10]1([CH2:9][S:8][C:6]2[NH:7][C:2]3[NH:1][C:19](=[O:21])[CH2:18][S:17][C:3]=3[C:4](=[O:16])[N:5]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 178473164HCID 178473164, compound

Product 1

HCID 178516922HCID 178516922, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of the product from step b) (0.30 g) in dry toluene (60 ml) was added p-toluene sulphonic acid (50 mg) and the solution heated under reflux for 11 hours. The resultant solid was collected by filtration, washed with ether and dried to give the subtitle compound as a colourless solid (0.290 g)

Workup

  1. temperaturethe solution heated
  2. temperatureunder reflux for 11 hours
  3. filtrationThe resultant solid was collected by filtration
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-236ec5744d18416c8ff4e5c9aff3e658
Source dataset
uspto-grants-2005_04
Patent number
US06875868B2

Reaction notes

Loading…