HCID 87952601, compound → HCID 22504144, compound

HRID 1814277Notes

Reaction equation

HRID 1814277 reaction equation
C([O:5][C:6](=[O:38])[CH2:7][CH:8]([NH:11][S:12]([C:15]1[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:24])[CH3:23])=[CH:17][C:16]=1[O:25][CH2:26][CH2:27][C:28]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[CH:31]=[CH:30][CH:29]=1)(=[O:14])=[O:13])[CH:9]=[O:10])(C)(C)C>C(Cl)Cl.FC(F)(F)C(O)=O>[C:22]([NH:21][C:18]1[CH:19]=[CH:20][C:15]([S:12]([NH:11][CH:8]([CH:9]=[O:10])[CH2:7][C:6]([OH:38])=[O:5])(=[O:13])=[O:14])=[C:16]([O:25][CH2:26][CH2:27][C:28]2[C:37]3[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:31]=[CH:30][CH:29]=2)[CH:17]=1)(=[O:24])[CH3:23]

Participants

4

Reactant 1

HCID 87952601HCID 87952601, compound

Product 1

HCID 22504144HCID 22504144, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 3-[4-acetylamino-2-(2-naphthalen-1-yl-ethoxy)-benzenesulfonylamino]-4-oxo-butyric acid tert-butyl ester (110 mg) in methylene chloride (6 mL) and trifluoroacetic acid (3 mL) was stirred at room temperature for 4 hours. The solvent was evaporated. The residue was triturated with ether and the resulting amorphous solid (58 mg) was collected by filtration.

Workup

  1. customThe solvent was evaporated
  2. customThe residue was triturated with ether
  3. filtrationthe resulting amorphous solid (58 mg) was collected by filtration

Sources & evidence

ORD record
ord-8bb7821d60034dd5a2522685ae573648
Source dataset
uspto-grants-2005_04
Patent number
US06875765B2

Reaction notes

Loading…