Hydrochloric Acid → HCID 22503413, compound

HRID 1814461Notes

Reaction equation

HRID 1814461 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([CH2:11][CH2:12][CH3:13])=[O:10])=[N:6][CH:7]=1.Br[C:15]1[N:16]=[C:17]([N:25]2[CH2:30][CH2:29][N:28]([CH2:31][CH3:32])[CH2:27][CH2:26]2)[C:18]2[C:23]([CH:24]=1)=[CH:22][CH:21]=[CH:20][CH:19]=2.[ClH:33]>>[ClH:33].[CH2:11]([C:9]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([C:15]2[N:16]=[C:17]([N:25]3[CH2:26][CH2:27][N:28]([CH2:31][CH3:32])[CH2:29][CH2:30]3)[C:18]3[C:23]([CH:24]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:7][N:6]=1)=[O:10])[CH2:12][CH3:13]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 876084N-(5-bromo-2-pyridinyl)butanamideHCID 225024471-(1-Ethylpiperazin-4-yl)-3-bromoisoquinoline

Product 1

HCID 22503413HCID 22503413, compound

Procedure

In the same manners sequentially as in Examples 161-2 and 20, the free compound of the title compound (338 mg, yield; 40%) from 5-bromo-2-propylcarbonylaminopyridine (3.11 g) and 3-bromo-1-(4-ethylpiperazin-1-yl)isoquinoline (514 mg). The resulting free compound was converted into a hydrochloride in a conventional manner, to give the hydrochloride of the title compound as yellow crystals.

Sources & evidence

ORD record
ord-7670bd348061409aa9496db3dd70637e
Source dataset
uspto-grants-2005_04
Patent number
US06875761B2

Reaction notes

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