Tetrahydrofuran → Methyl 2-[3-(1-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidine-1-yl]phenoxy}ethyl)phenoxy]propionate

HRID 181450Notes

Reaction equation

HRID 181450 reaction equation
[Cl:1][c:2]1[c:3]([OH:22])[cH:4][c:5](-[n:9]2[c:10](=[O:21])[n:11]([CH3:20])[c:12]([C:16]([F:17])([F:18])[F:19])[cH:13][c:14]2=[O:15])[c:6]([F:8])[cH:7]1.[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1.[OH:23][CH:24]([CH3:25])[c:26]1[cH:27][c:28]([O:29][CH:30]([C:31](=[O:32])[O:33][CH3:34])[CH3:35])[cH:36][cH:37][cH:38]1.[c:39]1([P:40]([c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)[c:47]2[cH:48][cH:49][cH:50][cH:51][cH:52]2)[cH:53][cH:54][cH:55][cH:56][cH:57]1>>[Cl:1][c:2]1[c:3]([O:22][CH:24]([CH3:25])[c:26]2[cH:27][c:28]([O:29][CH:30]([C:31](=[O:32])[O:33][CH3:34])[CH3:35])[cH:36][cH:37][cH:38]2)[cH:4][c:5](-[n:9]2[c:10](=[O:21])[n:11]([CH3:20])[c:12]([C:16]([F:17])([F:18])[F:19])[cH:13][c:14]2=[O:15])[c:6]([F:8])[cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 112677571-methyl-6-trifluoromethyl-3-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,4(1H,3H)-pyrimidinedioneHCID 18759644HCID 18759644, compound

Product 1

HCID 18759643Methyl 2-[3-(1-{2-chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidine-1-yl]phenoxy}ethyl)phenoxy]propionate

Sources & evidence

ORD record
ord-fb9e134f28c341e8a27e0f0088dae242
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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