Potassium Phosphate, Dibasic → HCID 22501863, compound

HRID 1814627Notes

Reaction equation

HRID 1814627 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:6]2=[O:20].[OH:21]P([O-])([O-])=O.[K+].[K+].OP([O-])(O)=O.[K+]>CS(C)=O.O>[CH:2]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:6]2=[O:20])=[O:21]

Participants

6

Reactant 3

HCID 24450Potassium Phosphate, DibasicHCID 516951Monobasic potassium phosphateHCID 22502293Ethyl 3-[5-bromomethyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]propionate

Product 1

HCID 22501863HCID 22501863, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

The crude material from step 2 was dissolved in DMSO (70 mL). Powdered K2HPO4 (18 g, 0.10 mol) and KH2PO4 (7 g, 0.05 mol) were added. The mixture was stirred at 80° C. for 5 hours, diluted with water (500 mL), and extracted with ethyl acetate (3×100 mL). The combined organic extracts were dried (MgSO4), and concentrated. After column chromatography (hexane, ethyl acetate 3:1) 4.8 g of the title compound was obtained.

Workup

  1. extractionextracted with ethyl acetate (3×100 mL)
  2. dry with materialThe combined organic extracts were dried (MgSO4)
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-ec78bd0d12954bc2ba2ae6fc04debc21
Source dataset
uspto-grants-2005_04
Patent number
US06875760B2

Reaction notes

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