反应详情

2-Isobutylamino-1 -morpholin-4-yl-ethanone (1.43 g, 7.13 mmol) was dissolved in 15 mL of THF. To this solution at −78° C. was added a solution of bromoacetyl bromide (1.24 mL, 14.3 mmol) in 15 mL of THF. The mixture was warmed to room temperature and stirred for 2 h. Solvent was removed in vacuo. The residue was dissolved in 30 mL of methylene chloride, washed with saturated sodium bicarbonate, and brine, then dried over sodium sulfate. The solvent was removed in vacuo and the residue was purified by silica gel flash chromatography eluting with 2% MeOH in methylene chloride to give 2-bromo-N-isobutyl-N-(2-morpholin-4-yl-2-oxo-ethyl)-acetamide (1.37 g, 60%) as a clear oil.

1. customSolvent was removed in vacuo
2. dissolutionThe residue was dissolved in 30 mL of methylene chloride
3. washwashed with saturated sodium bicarbonate, and brine
4. dry with materialdried over sodium sulfate
5. customThe solvent was removed in vacuo
6. customthe residue was purified by silica gel flash chromatography
7. washeluting with 2% MeOH in methylene chloride